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Cosmetic injection-induced nodules are tricky to handle in the clinic. We reported a case of injection-induced nodule receiving the experimental treatment of hyperbaric oxygen therapy (HOT). A woman presented with multiple red solid nodules on the neck after receiving mesotherapy conducted by syringe. Ultrasound examination showed multiple thickened inflammatory skin tissues on the neck. Pathological biopsy results showed epithelioid granulomas in the dermis, within which there were degenerative necrosis and foreign bodies in the center
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