https://www.selleckchem.com/pr....oducts/SB-431542.htm
The human leucocyte antigen (HLA)-B*2705 allele and the endoplasmic reticulum-resident aminopeptidases are strongly associated with ankylosing spondylitis (AS), a chronic inflammatory spondyloarthropathy. This study examined the effect of endoplasmic reticulum aminopeptidase 2 (ERAP2) in the generation of the natural HLA-B*2705 ligandome in live cells. Complexes of HLA-B*2705-bound peptide pools were isolated from human ERAP2-edited cell clones and the peptides were identified using high throughput mass spectrometry analyses. The rela
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