https://www.selleckchem.com/pr....oducts/lusutrombopag
Chrm4 was down-regulated following long-term alcohol and abstinence, while Chrm5 was up-regulated following long-term alcohol consumption. Consistent with these data, a positive allosteric modulator (VU0467154) of intra-vSub M receptors reduced context-induced alcohol-seeking, but not motivation for alcohol self-administration, while M receptor negative allosteric modulator (ML375) reduced initial motivation for alcohol self-administration, but not context-induced alcohol-seeking. Collectively, our data highlight alcohol-induced c
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