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Through multivariate analysis, stage (HR = 1.640, 95% CI = 1.019-2.642, = 0.042) and risk score (HR = 1.036, 95% CI = 1.026-1.046, 0.001). The genes (ARHGAP15, BTLA, CASS4, CLECL1, FAM129C, STAP1, TESPA1, and S100P) showed credible prognostic value in LUAD patients in TCGA through GEPIA database online analysis and verification in the Kaplan-Meier plotter database. In the microenvironment of lung adenocarcinoma, the differentially expressed genes screened by immune score and stromal score have certain value in evaluating the surviv