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4; P = 0.007); thus, the risk of purchasing opioids for those in the IR group was almost double (RR, 1.7 [95% CI, 1.1-2.6]). No significant or meaningful between-group differences in index joint pain, function, or mobility were observed. Contrary to what was hypothesized, IR is a strong driver of opioid purchase after discharge from the hospital following TKA. Contrary to what was hypothesized, IR is a strong driver of opioid purchase after discharge from the hospital following TKA. Patients with systemic lupus erythematosus (SLE) are us