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001) scores, and F18-fluorodeoxyglucose positron emission tomography (FDG-PET) uptake (p 0.001) than those with low FHS-CVD risk scores. In longitudinal analyses, individuals with higher FHS-CVD risk scores had greater longitudinal declines in MMSE (p = 0.043), EF (p = 0.029) scores, and FDG-PET uptake (p = 0.035). Besides, individuals with a higher vascular risk had an increased risk of clinical progression (p = 0.004). These findings indicated effects of vascular risk on cognitive decline, cerebral hypometabolism, and clinical pr