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The PD rat design had been founded by fixed-point injection of 6-hydroxydopamine into the rats. The PD rats had been inserted with miR-218-5p overexpressed recombinant adeno-associated virus (rAAV) or LASP1 silenced rAAV to explore their particular roles in dopaminergic neurons in SN of rats with PD. The alterations in pathological structure of SN had been observed and also the phrase of tyrosine hydroxylase (TH) and deacetylvindoline acetyltransferase (DAT), the dopaminergic neuron apop