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Graphical abstract Fluorescent gold nanoclusters (PSP-Y-AuNCs) fabricated using a non-toxic normal polysaccharide (PSP001) demonstrated pH sensitive fluorescence emission pattern. The enhanced fluorescence readouts at acid conditions and exemplary biocompatibility made the PSP-Y-AuNCs an appealing applicant for in vivo tumefaction imaging applications.Differentiation of stem cells could be modulated by a combination of internal and external signals, including mechanical cues through the surr