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ADHD Treatment For Adults The stimulants like methylphenidate amphetamine, and other brain chemicals can help increase levels. Nonstimulants, such as antidepressants and atomoxetine, work slower than stimulants but they can be beneficial too. Comorbid conditions can impact the effectiveness of ADHD medication. Physicians should address the most severe symptom of any co-occurring disorder first, and then check to see if the ADHD symptoms improve. Medication Medication is the most po