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Over the past decade, minimally invasive sacroiliac joint (SIJ) fusion has become an effective treatment for patients suffering from low back pain (LBP) originating from the SIJ. Perioperative C-arm fluoroscopy-assisted surgical navigation during SIJ fusion remains challenging due to the lack of 3D spatial information. This study developed and assessed a 3D CT/2D fluoroscopy integration approach based on digitally reconstructed radiographs (DRRs) obtained from pre-operative CT scans. Development of this approach proved feasible and lan