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The steam reforming of bio-oil-derived acetic acid over the developed Ni/CeO2-ZnO nanoparticle catalysts for hydrogen production was studied. The correlations of CeO2 to ZnO mass ratio (CZMR) and nickel loading with the properties and performances of Ni/CeO2-ZnO catalysts were explored. The H2, CO, and potential H2 yields followed a Gaussian normal distribution with increasing the CZMR. An exponential function equation was established to correlate the H2, CO, and potential H2 yields with Ni loading. As the CZMR increased from 0 to 1/3, th