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the strengths and limitations from the current available evidence. PROSPERO ID CRD42020172840. PROSPERO ID CRD42020172840. Leaves of the natural plant lotus are used in traditional Chinese medicine and tea production. They are rich in flavonoids. In this study, lotus leaf flavonoids (LLF) were applied to human lung cancer A549 cells and human small cell lung cancer cells H446 in vitro to verify the effect of LLF on apoptosis in these cells through the ROS/p38 MAPK pathway. LLF had no toxic effect on normal cells at concentrations up to