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Copyright © Inthong, et al.Aim the study aimed to review the result of interferon (IFN)-based drugs from the behavior of immunological parameters in calves throughout the certain avoidance of associative attacks. Materials and techniques the item of analysis was 45 black motley cattle and their calves from beginning to 2 months of life. Serum and colostrum examples had been screened for antibodies against Rotavirus, diarrhoea, and coronavir