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What Happens If ADHD is Left Untreated in Adults? Untreated ADHD can lead to a myriad of problems for adults. These can include issues with relationships, work and mental health. Often, adults with untreated ADHD have low self-esteem as well as a negative perception of the world. This can cause them to feel as if they are failing in their work and at home. Lack of Focus It is normal to experience difficulty focusing from time to time particularly after a hectic day at work or school. However, if you start to notice that your concentration has been d