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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the first-choice ADHD medications, they with the most research-based evidence behind them, and are quick-acting. However, they're not suitable for everyone. These drugs increase the communication between nerves and areas in the brain to lessen symptoms of ADHD. These medications can also cause side-effects like a change in blood pressure or heart rate, as well as an increase in appetite. Stimulants The most frequently used medication to treat ADHD is stimulants. They're known f