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ADHD Medication For Adults - What is the Most Effective ADHD Medication For Adults? Stimulant medication is the mainstay of ADHD treatment However, they don't work for everyone. Antidepressants and nonstimulant medications can help. Adults with ADHD can take pills or patches, or liquids. They improve concentration and reduce the impulsive behavior. They are prescribed by a doctor when stimulants fail to work or cause side