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We discuss some feasible programs and properties of the recently introduced metrics, such their particular upper and lower bounds. Distinctiveness centrality provides a viewpoint of centrality option to compared to founded metrics.Background DNA plasmids vow a pragmatic alternative to viral vectors for prime-boost HIV-1 vaccines. We evaluated DNA plasmid versus canarypox virus (ALVAC) primes in 2 randomized, double-blind, placebo-controlled trials in southern