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This study was undertaken with the aim of better understanding the genomic landscape of core-binding factor (CBF) acute myeloid leukemia (AML). We retrospectively analyzed 112 genes that were detected using next-generation sequencing in 134 patients with de novo CBF-AML. , and mutations were detected by DNA-PCR and Sanger sequencing. In the whole cohort, the most commonly mutated genes were (33.6%) and (33.6%), followed by (18.7%), (13.4%), (8.2%), and (8.2%). The frequencies of mutated genes associated with epigenetic modification, such
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