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A similar behavior was observed in patients with macroalbuminuria or normoalbuminuria (p = 0.219, and 0.109, respectively), with a significant trend in those with microalbuminuria (p = 0.019). Even in patients with HbA1c less then 7, high HbA1c_CV also predicts rapid eGFR decline. Before macroalbuminuria, minimizing HbA1c_CV also has renal benefit. Conclusions HbA1c variability is an independent risk factor for deterioration of renal function. Even with well-controlled HbA1c levels ( less then 7%), patients with high HbA1c_CV still e