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Resuof controls. Conclusion Severe bilateral carotid stenosis induced mild cognitive dysfunction and slight architectural alterations in the brains of elderly rats. Thus, a chronic cerebral hypoperfusion model was effectively founded. Copyright © 2020 Wang, Yang, Wang, Li, Li, sunlight, Zhao, Ma, Hua and Yang.Hypertension is considered as a risk aspect for Alzheimer condition, but the causal website link remains undetermined. Although astrocytes and microglia play a crucial role in