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A retrospective case series with a so-called high-dose antihistamine therapy with non-sedating antihistamines was effective in treating chronic pruritus. This article summarizes the possibilities of systemic antihistamines in pruritus, especially with regard to limitations and future prospects.Background The mutual exchange of results between basic sciences and clinical research as well as their translation into practice, also with regard to chronic pruritus, is currently to be seen as an ambition or hope rather than established practice. Objective