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Main results. Intriguingly, this data-driven approach showed that the best classification performance was achieved using three EEG channel pairs located in the NHB area. The mixed features of the frontal NHB area lead to the high within-subject detection rate of driving fatigue (92.7% ± 0.92%) with satisfactory generalizability for fatigue classification across different subjects (77.13% ± 0.85%). Moreover, we found the most prominent contributing features were PSD of different frequency bands within the frontal NHB area and FC withi