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Serum copeptin and albumin-bilirubin scores were independent predictors of ascites retention. The short-term and long-term cumulative mortality rate was significantly decreased in patients with serum copeptin 5.5 or 4.8pmol/mL compared with patients in whom serum copeptin levels were 5.5 or 4.8pmol/mL (P0.0001; P0.0001). Serum copeptin level is a predictor for ascites retention and HE and PSS formation associated with portal hypertension. Moreover, serum copeptin level may be useful in predicting the rate of surviv