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23±31.84months later remained symptomatic. CIBP in FDRs of AS patients is HLA-B27-associated, has earlier onset and tends to persist compared to NICBP. CIBP in FDRs of AS patients is HLA-B27-associated, has earlier onset and tends to persist compared to NICBP. To determine the relationship between synovial versus skin transcriptional/histological profiles in patients with active psoriatic arthritis (PsA) and explore mechanistic links between diseased tissue pathology and clinical outcomes. Twenty-seven active PsA patients were enrolled i