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We report an incident of an 81-year-old male with recent elimination of an infected right knee prosthesis and insertion of an articulating antibiotic spacer, showing from rehabilitation for serious thrombocytopenia (1 X 103/µL). The patient's thrombocytopenia was falsely related to rifampin-induced ITP, an infinitely more common cause of drug-induced thrombocytopenia. Just later, after an additional precipitous fall in platelet count, vancomycin ended up being properly identified as the culprit. The patient'
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