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SARS-CoV-2 continues to spread and mutate in Israel and across the globe. With economy and travel resuming, surveillance of clades and accumulating mutations is crucial for understanding its evolution and spread patterns and may aid in decision making concerning public health issues.Among over 200 COVID-19 affected countries, some are fighting to "flatten the curve", while some others are considering reopening after lockdown. It remains unclear how different reopening strategies obstruct the local virus containment and impact the economy