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Thus, the surviving GCs after Cy exposure had intact AMH-producing ability. In future, an effort to minimize GC death by Cy treatment is required, while maintaining its therapeutic effects. We determined the predictors of osteonecrosis in a longitudinal lupus cohort, emphasizing the role of maximal prednisone dose and duration. Data from 2428 patients were included in the analysis based on 224295 person-months of follow-up. We used pooled logistic regression to assess the relationship between risk factors and rates of osteonecrosis. After identifying a set