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One of the foundational assumptions in education is that greater teacher knowledge contributes to greater gains in student knowledge, but empirical evidence in support of this assumption is scarce. Using a U.S. sample of 79 biology teachers and their 2749 high school students, we investigate whether teachers' subject matter knowledge (SMK) and knowledge of students' misconceptions (KOSM) in high school life science are associated with students' posttest performance on multiple-choice test items designed to reveal student misconceptions,