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From mechanistic studies including theoretical calculations, it is shown that electronic interaction is allowable between the aryl substituent to the π-conjugated system through the tetradentate boron.Infectious or immune diseases have caused serious threat to human health due to their complexity and specificity, and emerging drug delivery systems (DDSs) have evolved into the most promising therapeutic strategy for drug-targeted therapy. Various mesoporous biomaterials are exploited and applied as efficient nanocarriers to loading drugs by