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In PD, AD, and MCI, the rate of B12 decline ranged from - 17 to - 47 pg/ml/year, much greater than that reported for the elderly population. Conclusions Further studies are needed to determine whether comorbid B12 deficiency affects progression of these disorders. © The Author(s) 2020.Little is actually known about the nature and characteristics of the cognitive dissonance state. In this paper, we review the actual knowledge and the main limitations of past studies. Then, we present two studies that investigate the characteristics of