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29 ± 0.13 of foci/nucleus and 17.07% ± 7.68 more DSB bearing cells (p less then 0.05). The cocktail treated group showed a lower difference average of - 2.79% ± 6.13 DSB bearing cells. A paired t-test revealed a significant difference between the groups (p less then 0.005) confirming the cocktail's protective effect. The novel anti-oxidant treatment decreases the oxidative stress-induced DNA damage and can be considered as a preventative treatment before radiation exposure.Genetically-encoded calcium indicators (GECIs) are essential