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Here, we propose a broader hypothesis of encoding, consolidation, and renormalization in depression (ENCORE-D), which implies that, fundamentally, fast and sustained antidepressant impacts rely on intrinsic homeostatic mechanisms evoked as an answer into the intense pharmacological or physiologic effects set off by the procedure. We examine proof that supports the notion that different treatments with a rapid start of action, such as for example ketamine, electroconvulsive treatmen