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In this review, we summarize our current understanding of the role of human A3 proteins as barriers against HIV-1 infection, how Vif overcomes their antiviral activity, and highlight recent structural and functional insights into A3-mediated restriction of lentiviruses.Advanced thermoplastic composites manufacturing using laser assisted tape placement or winding (LATP/LATW) is a challenging task as monitoring and predicting nip point (bonding) temperature are difficult especially on curved surfaces. A comprehensive numerical analysis of