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Treatment For ADHD The most effective treatments for add are medication and psychosocial therapy (psychotherapy). Medications can include stimulants like methylphenidate and amphetamine, and non-stimulants such as atomoxetine, viloxazine, guanfacine, and clonidine. Patients with active substance abuse issues shouldn't take stimulant drugs. However, those in stable remission can take them into consideration. Combination therapy with antidepressants, particularly SSRIs, is an alternative option. Stimulants The effects of stimulants increase the levels