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Halogen bonding (X to your selenium associated with selenocysteine (Sec) residue when you look at the Dio active site is suggested to play a role in the mechanism for iodine removal. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) tend to be known disruptors of numerous paths for the urinary tract. Experimental evidence shows PBDEs and their hydroxylated metabolites (OH-BDEs) can inhibit Dio, while information regarding PCB inhibition tend to be restricted. These xenobiotics could prevent
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