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The Most Effective ADHD Medication For Adults Stimulants are the most effective medication for adults with ADHD. They aid in adjusting levels of two chemical messengers within the brain that control the ability to pay attention. Strattera (atomoxetine) is the most effective medication for adhd available for adults. It is an oral capsule that can be taken either with or without food. It works well for most people. It also lasts longer than the less powerful stimulants, like ampheta