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The third patient had elected to defer radiotherapy and oncology treatment and was lost to follow-up. The mean progression-free survival was 3.55 months, with interval satellite lesions seen on follow-up imaging studies. Although our case series was small, we have demonstrated for the first time, to the best of our knowledge, that bilateral LITT is a safe and effective treatment of GBM of the corpus callosum. Given the known benefit of near gross total resection for high-grade glioma, we believe LITT might improve survival for these pati