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The lipid peroxidation, and the antioxidant enzyme activities in the cells correlated well with the reactive species generation results. The treatments with the mixture resulted in notable enhancement in the esterase activity in the cells. The Independent Action model suggested antagonistic interactions between PSNPs and nano-TiO2. The results from this study clearly demonstrate that nano-TiO2 in presence of the PSNPs exerted significantly reduced cytotoxic effects in Chlorella sp, in comparison with the pristine particles.Our study implies th