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ADHD Medications For Adults Stimulants aid in adjusting the levels of chemical messengers in the brain, which control attention. They are first-line medications in the treatment of ADHD. Although they are not in any way habit-forming, they can trigger adverse effects like headaches and difficulty sleeping. Your doctor may also prescribe guanfacine (brand names Tenex and Intuniv) or Clonidine (Catapres) to reduce hyperactivity and impulsivity. have a longer acting than stimulants.