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Study design Retrospective chart review. Objectives The objective of this study was to characterize opioid administration in people with acute SCI and examine the association between opioid dose and (1) changes in motor/functional scores from hospital to rehabilitation discharge, and (2) pain, depression, and quality of life (QOL) scores 1-year post injury. Setting Spinal Cord Injury Model System (SCIMS) inpatient acute rehabilitation facility. Methods Patients included in the SCIMS from 2008 to 2011 were linked to the National Trauma Reg