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All in all, DDX11-AS1 promotes NSCLC development via regulating PI3K/AKT signaling. This article is protected by copyright. All rights reserved.Peroxisome proliferator-activated receptor-gamma (PPARγ) coactivator-1α (PGC1α) is a key regulator of mitochondrial biogenesis and respiration. PGC1α is involved in the carcinogenesis, progression, and metabolic state of cancer. However, its role in progression of hepatocellular carcinoma (HCC) remains unclear. In this study, we observed that PGC1α was downregulated in human HCC. A clinical stud