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Renal impairment (RI) is associated with poor survival in newly diagnosed multiple myeloma (MM) patients. Renal function recovery has been one of the main therapeutic goals in those patients. The records from 393 newly diagnosed MM patients in our hospital between January 2012 and December 2016 were retrospectively analyzed. RI was defined as an eGFR40mL/min according to the novel IMWG criteria. RI patients were categorized based on their renal function at diagnosis severe RI eGFR30mL/min, and mild RI 30mL/min≤eGFR 40mL/min.