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Combining HOMA-%β and HOMA-IR did not improve performances. Within both age groups, HOMA-%β 100 provided good sensitivity and NPV. HOMA-IR 1 had low sensitivity. Calculation of the HOMA-%β could be an interesting first-line screening approach to exclude CFRD and thus avoid unnecessary OGTT in patients for whom value is ≥100. However, HOMA-%β100 does not support the diagnosis of CFRD and should be complemented by OGTT. 1 had low sensitivity. Calculation of the HOMA-%β could be an interesting first-line screening appr