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Central line-associated bloodstream infections (CLABSIs) can result in increased morbidity and mortality and billions of dollars of costs per year to institutions and patients. Fluctuating availability of manufacturers' supplies of intravenous (IV) solutions have created issues for health systems in which policy and procedures have been examined regarding extended hang time for IV solutions. This article examined the relationship between extended hang times of nonadditive IV solutions and incidence of CLABSIs in intensive and general pr