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For bleeding outcomes, ≤3months DAPT was associated with significant reduction in bleeding compared to 6months, 12months or 12months DAPT (OR [95% CI] 0.60 [0.37-0.98]; 0.68 [0.54-0.85] and 0.43 [0.34-0.54], respectively). These findings were similar when limited to 2nd generation DES. Data from this meta-analysis of randomized trials support short-term (≤3months and 6months) DAPT in patients with ACS undergoing PCI. Guidelines might need to consider short-term DAPT even in patients presenting with ACS, especially in this era of newe