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To a self-etch adhesive doped with nano-bioglass and evaluate its ability to bond and re-mineralize artificially demineralized dentin. Experimental Si, Ca, Na and PO based nanobioglass particles were synthesized, doped into experimental self-etch adhesives, and divided into 3 groups Clearfi SE2 (CSE2), experimental (EXC), and experimental doped with 10% of nanobioglass (ExN. The adhesives were applied onto the caries-affected dentin (chemically simulated), and evaluated after 24 h and 28 days of immersion in simulated body fluid. The re