What Causes Trucking Accidents? Trucks make up a tiny portion of the vehicles on road, but they are a risk and can cause severe injuries or even death. Accidents involving large vehicles can occur when drivers become distracted or fail to pay attention to their blind spots. Driver fatigue is also a factor in trucking accidents. Drivers work for long hours without taking breaks in order to meet their limits. Driver Error Driver error is the most common cause of trucking accidents and it's a serious problem. There are many factors that contribu