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In the present research, we aimed to gauge the functional system of glycosides extracted from Caulis Lonicerae regarding the inflammatory expansion of interleukin-1 beta (IL-1β)-mediated fibroblast-like synoviocytes (FLSs) from rats. Rat FLSs (RSC-364) co-cultured with lymphocytes caused by IL-1β were used as a cell design. Glycosides in a freeze-dried dust of aqueous extract from Caulis Lonicerae had been identified using high-performance liquid chromatography-electrospray ioni