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Overall, this implies that SPX may be the cause in reproduction in the level of the hypothalamus together with pathways through which Spx, Galr2 and Galr3 are modified by fatty acids could offer understanding of the systems underlying reproductive dysfunction in obesity.The hypothalamic-pituitary axis (HP axis) plays a crucial and integrative part into the urinary tract control to keep homeostasis. The HP axis accounts for the hormone events required to