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The LUZ had a significant lower grading score than the right upper zone 1 versus 2 (p less then 0.001). Likewise, the upper zones had a significant lower score than the mid and lower zones (p less then 0.001). Our findings confirmed the relative sparing of the LUZ in severe COVID-19 pneumonia. We performed a systematic review and meta-analysis to investigate the clinical significance of hyperdense area after thrombectomy in patients with acute ischemic stroke (AIS). We searched Ovid MEDLINE(R) and Epub Ahead of Print, In-Process and